Mucokinetica Ltd. is a biopharmaceutical company focused on the discovery and development of medicines to treat respiratory diseases. Our key expertise is in the treatment of diseases where accumulated mucus secretions are an important contributor to disease pathology. Such diseases include:
Every day of our lives we breathe in thousands of litres of air. The air carries dust, pollen, dander, bacteria and other microbes into the lungs.
Mucus secretions are an important component of a very sophisticated refuse disposal system that works day and night to keep our airways clean. It removes the inhaled debris that adheres to and is engulfed by mucus gel lining the airways.
The engine of this refuse disposal system is the surface layer of ciliated cells that populate all but the smallest airways in the lungs.
Mucociliary propulsion is a surface process. All of the action for effective movement takes place between the beating cilia and the 5 to 10 one-thousandth of a millimetre contact surface layer of mucus gel.
Mucus gel has both viscous and elastic properties essential for mucociliary propulsion. Mucus is a so-called "Smart" gel. A gel that is able to adjust its properties in response to the composition of its local fluid environment.
Cells of the epithelium regulate the composition of the fluid layer between the cilia and the surface of the mucus gel. Proficiency of mucociliary propulsion is controlled by:
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